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Image Search Results
Journal: Clinical Case Reports
Article Title: A prenatal case of partial trisomy 21 (q22.2q22.3), resulting from a paternal insertion translocation ins(16;21) and uncovered by QF‐PCR, and characterized by array CGH and FISH
doi: 10.1002/ccr3.1563
Figure Lengend Snippet: (A) QF‐PCR of fetus showing triallelic trisomy pattern for the STR marker D21S1411 (21q22.3) (red box); (B) additional STR marker, D21S1412 (21q22.2), showing triallelic trisomy pattern; (C) 180K microarray showing a duplication approximately 4.98 Mb of parts of chromosome bands 21q22.2 and q22.3; (D) FISH on fetal material showing a submicroscopic insertion of chromosome band 21q22.2q22.3 in the long arm of chromosome 16; and (E) FISH on the patient's partner showing a balanced interchromosomal insertion: 46,XY.ish ins(16;21)(q22;q22.2q22.3).
Article Snippet:
Techniques: Marker, Microarray
Journal: Disease Models & Mechanisms
Article Title: Ts66Yah, a mouse model of Down syndrome with improved construct and face validity
doi: 10.1242/dmm.049721
Figure Lengend Snippet: Generation and validation of the new Ts66Yah mouse model. (A) Representation of the deletion produced in Ts65Dn using CRISPR/Cas9 and two pairs of gRNAs. (B) Sequence electropherogram and PCR amplification products from the genotyping of Ts66Yah mice. (C) Genomic sequence of the new junction found in the deleted minichromosome of Ts66Yah mice. Blue font shows PCR primer localizations. (D) One metaphase spread showing the presence of an additional minichromosome (arrow) in Ts66Yah fibroblasts. (E) Comparative genomic hybridization (log2) of genomic DNA from Ts66Yah mice versus wild type (180K probes) compared to Ts65Dn mice (two 100K probes). (F) Comparison of the Ts66Yah and Ts65Dn minichromosomes. Orange and red colors show the sequence of Mmu17 and Mmu16, respectively. Numbers with letters represent the Giemsa banding.
Article Snippet: After labeling, the DNAs were hybridized on
Techniques: Produced, CRISPR, Sequencing, Amplification, Hybridization